Open for Recruitment

Breast Cancer
Colorectal Cancer
Phase II: Protocol Number AGITG AG1013GST

A randomised phase II trial of imatinib alternating with regorafenib compared to imatinib alone for the first line treatment of advanced gastrointestinal stromal tumour (GIST).

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Phase III: Boston CanStem303C CRC

A phase III study of BBI-608 in combination with 5-Fluorouracil, Leucovorin, Irinotecan (FOLFIRI) in adult patients with previously Treated Metastatic Colorectal Cancer (CRC)

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Gastric and Gastro-Esophageal Junction Cancer
Lung Cancer
Phase III: BR.31

A phase III prospective double blind placebo controlled randomized study of adjuvant MEDI4736 in completely resected non-small cell lung cancer.

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Phase II/III: Protocol Number 1199.93 LUME

Double blind, randomised, multicentre, phase II/III study of nintedanib in combination with pemetrexed/cisplatin followed by continuing nintedanib monotherapy versus placebo in combination with pemtrexed/cisplatin followed by continuing placebo monotherapy for the treatment of patients with unresectable malignant pleural mesothelioma.

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Phase III: Protocol Number AP26113-13-301

A phase 3 multicenter open-label study of Brigatinib (AP26113) versus Crizotinib in patients with ALK-positive advanced lung cancer.

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Phase II: Protocol Number MM-121-01-02-09

A phase 2 study of MM-121 in combination with docetaxel or pemetrexed versus docetaxel or pemetrexed alone in patients with heregulin positive, locally advanced or metastatic non-small cell lung cancer.

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Phase III: Protocol Number BPI-2358-103 (Beyond Spring)

Randomized blinded phase 3 assessment of second-or third line chemotherapy with docetaxel + plinabulin compared to docetaxel + placebo in patients with advanced non-small cell lung cancer with at least 1 large lung lesion.

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Phase I+II: Protocol ABBVIE-M14-361

A phase 1 dose escalation and phase 2 randomized double-blind study of veliparib in combination with carboplatin and etoposide as a therapy of treatment-naïve extensive stage disease small cell lung cancer incorporating administrative change 1 and amendments 1, 2 and 3.

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BMS CA209234 (NIVOPASS)

Pattern of use and safety/effectiveness of nivolumab in routine oncology practice.

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Mesothelioma
Lymphoma
Phase I: Protocol Number HMPL-523 Hutchision

A phase I, open-label, dose-escalation study of the safety and pharmacokinetics of HMPL-523 in patients with relapsed or refractory Hematologic Malignancies 

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 Protocol Number GS-US-313-1580

Dose optimization study of idelalisib in follicular lymphoma and small lymphocytic lymphoma.

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Phase III: Protocol Number 20130109

A randomized, double-blind study evaluating the efficacy, safety and immunogenicity of ABP 798 compared with rituximab in subjects with CD20 positive B-cell Non-Hodgkin Lymphoma (NHL)

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Myelodysplastic Syndrome (MDS)
Pancreatic Cancer
Phase III: Protocol Number HALO-109-301

A phase 3, randomized, double-blind, placebo-controlled, multicentre study of PEGylated recombinant human hyaluronidase (PEGPH20) in combination with nab-paclitaxel plus gemcitabine compared with placebo plus nab-paclitaxel and gemcitabine in subjects with hyaluronan-high stage IV previously untreated pancreatic ductal adenocarcinoma

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Prostate Cancer
Urothelial Cancer
Renal Cancer
Solid Tumours
PHASE I: AbbVie M15-862

A Multi-Center, Phase 1, Open-Label, Dose-Escalation Study of ABBV-927, an Immunotherapy, in Subjects With Advanced Solid Tumors

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Ongoing (Not Recruiting)

Breast Cancer
Phase III: EMBRACA

A phase 3, open-label, randomized, parallel, 2-arm, multi-center study of talazoparib (BMN 673) versus physician’s choice in germline BRCA mutation subjects with locally advanced and/or metastatic breast cancer, who have received prior chemotherapy regimens for metastatic disease.

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Phase III: Protocol WO29522 IMpassion130

A phase III, multicenter, randomized, placebo-controlled study of MPDL3280A (anti−PD-L1 antibody) in combination with nab-paclitaxel compared with placebo with nab-paclitaxel for patients with previously untreated metastatic triple-negative breast cancer.

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Phase II Extension Study : Protocol TDM4529g/BO25430

This is a global, multicenter, open-label extension study. Patients receiving single-agent T-DM1 or combination T-DM1 administered in combination with paclitaxel or with pertuzumab ± paclitaxel in a Genentech/Roche-sponsored study who completed the parent study or who continue to receive study drug(s) at the time of the parent study closure are eligible for continued treatment on this protocol.

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Phase II: Protocol GO29689

A phase II, open-label, randomized study of GDC-0810 versus fulvestrant in postmenopausal women with advanced or metastatic ER+ /HER2 − breast cancer resistant to aromatase inhibitor therapy.

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Lung Cancer
Phase III: Protocol D5164C00001 (ADAURA)

A phase III, double-blind, randomized, placebo-controlled multi-centre, study to assess the efficacy and safety of AZD9291 versus placebo in patients with epidermal growth factor receptor mutation positive stage IB-IIA non-small cell lung carcinoma, following complete tumour resection with or without adjuvant chemotherapy.

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Phase II: Protocol Number HM-EMSI-202

A single-arm, open-label, phase 2 study evaluating the efficacy, safety and pharmacokinetics of HM61713 in patients with T790M-positive non-small cell lung cancer (NSCLC) after treatment with an epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI)

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Phase II: AVEO-AV-299-14-206

A phase 2, multicenter, randomized, double-blind study of ficlatuzumab plus erlotinib versus placebo plus erlotinib in subjects who have previously untreated metastatic, EGFR-mutated non-small cell lung cancer (NSCLC) and BDX004 Positive Label.

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Phase III: Protocol Number GO29438 (ImPower)

A phase III, open-label, randomized study of atezolizumab (mpdl3280a, anti−pd-l1 antibody) in combination with carboplatin or cisplatin+pemetrexed compared with carboplatin or cisplatin+pemetrexed in patients who are chemotherapy-naive and have stage iv non-squamous non−small cell lung cancer.

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Gastric and Gastro-Esophageal Junction Cancer
Phase III: Protocol Number GS-US-296-1080

A phase 3 randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of GS-5745 combined with mFOLFOX6 as first line treatment in patients with advanced gastric or gastroesophageal junction adenocarcinoma.

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Phase III: Protocol Number BBI608-336

A phase III randomized, double-blind, placebo-controlled clinical trial of BBI608 plus weekly paclitaxel vs. placebo plus weekly paclitaxel in adult patients with advanced, previously treated gastric and gastro-esophageal junction adenocarcinoma.

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Colorectal Cancer
Phase III: Protocol Number GO30182

A phase III, open-label, multicentre, three-arm, randomized study to investigate the efficacy and safety of cobimetinib plus atezolizumab and atezolizumab monotherapy vs. regorafenib in patients with previously treated unresectable locally advanced or metastatic colorectal cancer.

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Prostate Cancer
Phase III: ENZAMET ANZUP1304

A randomized phase 3 trial of enzalutamide in first line androgen deprivation therapy for metastatic prostate cancer.

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Additional Information

Urothelial Cancer
Phase II: BL.12
A multicentre randomized phase II trial comparing nab-paclitaxel to paclitaxel in patients with advanced urothelial cancer progressing on or after a platinum containing regimen.

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